N-(3-甲酰基-2-吡啶基)-2,2-甲基丙酰胺合成路线 （共 12 条）
反应条件
1: N-(2-pyridinyl)-2,2-dimethylpropanamide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 0°C;
参考文献
Dr. Karl Thomae GmbH
Patent: US6344449 B1, 2002 ;
Location in patent: Page column 130-131 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C; 63 h;
参考文献
US2006/94707 A1, ;
Page/Page column 49 ;
US 20060094707 A1
反应条件
1: N-(2-pyridinyl)-2,2-dimethylpropanamide With tert.-butyl lithium in diethyl ether; pentane T=-78°C; 1.5 h; 2: (4-morpholinyl)methanone in tetrahydrofuran; pentane T=-78 - 20°C;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1782811 A1, 2007 ;
Location in patent: Page/Page column 59 ;
反应条件
1: N-(2-pyridinyl)-2,2-dimethylpropanamide With tert.-butyl lithium in diethyl ether; pentane T=-78°C; 1.5 h; 2: (4-morpholinyl)methanone in diethyl ether; pentane T=-78 - 20°C;
参考文献
Eisai Co., Ltd.
Patent: EP1669348 A1, 2006 ;
Location in patent: Page/Page column 67 ;
反应条件
1: N-(2-pyridinyl)-2,2-dimethylpropanamide With n-butyllithium in tetrahydrofuran; hexane T=-20°C; 2 h; 2: 1-piperidinecarboxaldehyde in tetrahydrofuran; hexane T=-20 - 20°C; 18.5 h;
参考文献
EP1218005 B1, ;
Page 21 ;
反应条件
triethylamine in dichloromethane; water
反应条件
n-butyllithium; potassium carbonate in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane
反应条件
pyridine in tetrahydrofuran
反应条件
1.1: 94 percent / Et3N / various solvent(s) / 2 h / 20 °C 2.1: t-BuLi / pentane; various solvent(s) / 2.5 h / 0 °C 2.2: pentane; various solvent(s) / 0 - 20 °C 2.3: 90 percent / aq. HCl / pentane; various solvent(s) / -10 - 0 °C View Scheme
参考文献
Synthetic Communications, , vol. 31, # 10 p. 1573 - 1579
反应条件
1: 79 percent / triethylamine / CH2Cl2 / 2 h / Ambient temperature 2: 1) n-BuLi, 2) 6 N HCl / THF, hexane 1.) 0 degC, 4h, 2) -78 deg C to room temp. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 20 p. 3401 - 3408
