反应条件
1: 90 percent / 2,6-lutidine, KF, 18-crown-6 ether / CH2Cl2 / 0.5 h / Ambient temperature 2: 11 percent / 1.) molecular sieves 4 Angstroem, 2.) BF3*Et2O / CH2Cl2 / 0.33 h / -40 °C 3: 76 percent / H2 / Pd/C / ethyl acetate; methanol / 1 h / 760 Torr / Ambient temperature View Scheme
参考文献
Rathore, Hargovind; From, Arthur H. L.; Ahmed, Khalil; Fullerton, Dwight S.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1945 - 1952
