4-(1-咪唑基)苯甲酸乙酯合成路线 （共 14 条）
反应条件
copper(l) iodide; potassium carbonate; L-proline; PS[DMVBIM][Pro] in dimethyl sulfoxide T=90°C; 60 h;
参考文献
Huang, Li; Jin, Can; Su, Weike
Chinese Journal of Chemistry, 2012 , vol. 30, # 10 p. 2394 - 2400
反应条件
4,4'-dimethyl-2,2'-bipyridine; oxygen; copper diacetate in water T=20°C; Chan-Lam coupling; P=760.051 Torr; 24 h;
参考文献
Inamoto, Kiyofumi; Nozawa, Kanako; Kadokawa, Jun; Kondo, Yoshinori
Tetrahedron, 2012 , vol. 68, # 38 p. 7794 - 7798
反应条件
potassium phosphate; copper(l) iodide in N,N-dimethyl-formamide T=35 - 40°C; 40 h; Inert atmosphere; chemoselective reaction;
参考文献
Zhu, Liangbo; Li, Gaocan; Luo, Liang; Guo, Peng; Lan, Jingbo; You, Jingsong
Journal of Organic Chemistry, 2009 , vol. 74, # 5 p. 2200 - 2202
反应条件
sodium hydride in dimethyl sulfoxide T=100°C; 18 h;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: ethane-1,2-dial; 4-amino-benzoic acid ethyl ester in methanol; water T=20°C; 16 h; 2: formaldehyd With phosphoric acid; ammonium chloride in methanol; water Heating;
参考文献
Ahrens, Sebastian; Herdtweck, Eberhardt; Goutal, Sigrid; Strassner, Thomas
European Journal of Inorganic Chemistry, 2006 , # 6 p. 1268 - 1274
反应条件
potassium iodide in hexane
参考文献
Janssen Pharmaceutica N.V.
Patent: US4962115 A1, 1990 ;
反应条件
in N,N-dimethyl-formamide
反应条件
1: With ammonium chloride in methanol; water 1 h; Reflux; 2: With phosphoric acid in methanol; water 4 h; Reflux; 3: With potassium hydroxide in methanol; water pH=9;
参考文献
Schulz, Tobias; Ahrens, Sebastian; Meyer, Dirk; Allolio, Christoph; Peritz, Anke; Strassner, Thomas
Chemistry - An Asian Journal, 2011 , vol. 6, # 3 p. 863 - 867
反应条件
sodium tetrahydroborate; calcium chloride in tetrahydrofuran Ambient temperature;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: 57 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature 2: 51 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
