hydrogenchloride in tetrahydrofuran; methanol T=20°C; 96 h;

1: 82 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating 2: 80 percent / aq. HCl / tetrahydrofuran; methanol / 96 h / 20 °C View Scheme

1: 82 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating 2: 80 percent / aq. HCl / tetrahydrofuran; methanol / 96 h / 20 °C View Scheme

1.1: n-BuLi; TMEDA / diethyl ether; hexane / 1.5 h / Heating 1.2: 79 percent / I2 / diethyl ether; hexane / -78 - 20 °C 2.1: 82 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating 3.1: 80 percent / aq. HCl / tetrahydrofuran; methanol / 96 h / 20 °C View Scheme