(S)-2-(甲苯磺酰氧基甲基)吡咯烷-1-甲酸叔丁酯合成路线 （共 28 条）
反应条件
1.1: sodium / dioxane / 15 h / Heating 1.2: 93 percent / dioxane; tetrahydrofuran / 19 h / 20 °C 2.1: trifluoroacetic acid / 2 h / 0 °C 2.2: 90 percent / aq. ammonia / CHCl3 / 0.17 h / 20 °C View Scheme
参考文献
Nakagawa, Yuichi; Kanai, Motomu; Nagaoka, Yasuo; Tomioka, Kiyoshi
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7805 - 7808
反应条件
lithium bromide in acetone 6 h; Reflux;
参考文献
Xu, Da-Zhen; Liu, Yingjun; Shi, Sen; Wang, Yongmei
Tetrahedron Asymmetry, 2010 , vol. 21, # 20 p. 2530 - 2534
反应条件
1: NaN3 / dimethylsulfoxide / 19 h / 64 °C 2: PPh3; H2O / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Wroblewska, Aneta; Mloston, Grzegorz
Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 4 p. 509 - 511
反应条件
lithium iodide in tetrahydrofuran Reflux;
参考文献
Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam
Tetrahedron, 2013 , vol. 69, # 2 p. 527 - 536
反应条件
in dimethyl sulfoxide T=90°C; 6.5 h;
参考文献
SHIONOGI and CO., LTD.
Patent: WO2006/116764 A1, 2006 ;
Location in patent: Page/Page column 121; 133 ;
反应条件
in dimethyl sulfoxide T=100°C; 4 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; MARUYAMA, Megumi; KINOMURA, Naoya; NOJIMA, Satoshi; TAKAMURA, Masahiro; KAKIGUCHI, Keisuke; TATAMITANI, Hiroto
Patent: WO2011/111875 A1, 2011 ;
Location in patent: Page/Page column 63-64 ;
WO 2011/111875 A1
反应条件
in dimethyl sulfoxide T=110°C; 3 h;
参考文献
JAMES BLACK FOUNDATION LIMITED
Patent: EP1056733 B1, 2004 ;
Location in patent: Page 34 ;
反应条件
sodium azide in N,N-dimethyl-formamide T=70°C; 6 h;
参考文献
Saha, Satyajit; Seth, Saona; Moorthy, Jarugu Narasimha
Tetrahedron Letters, 2010 , vol. 51, # 40 p. 5281 - 5286
反应条件
1: phenol With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: tert-butyl (2S)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1-pyrrolidinecarboxylate in tetrahydrofuran 12 h; Heating;
参考文献
Kopka, Klaus; Faust, Andreas; Keul, Petra; Wagner, Stefan; Breyholz, Hans-Joerg; Hoeltke, Carsten; Schober, Otmar; Schaefers, Michael; Levkau, Bodo
Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6704 - 6715
反应条件
1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 12 h / Heating 2.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Lee; Long; Murray; Adams; Nuttall; Nadeau; Kikly; Winkler; Sung; Ryan; Levy; Keller; DeWolf Jr.
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 2015 - 2026
