7-乙基-10-羟基喜树碱合成路线 （共 84 条）
反应条件
1: 4-piperidinopiperidinecarbamoyl chloride hydrochloride; SN-387 lactone With triethylamine in pyridine; dichloromethane T=30 - 40°C; 1.5 h; 2: 4-(1-piperidyl)piperidine in pyridine; dichloromethane 0.5 h;
参考文献
FERMION OY
Patent: WO2006/84940 A1, 2006 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: With pyridine; triethylamine in dichloromethane T=30 - 40°C; 1.5 h; 2: With 4-(1-piperidyl)piperidine in dichloromethane T=0 - 80°C; pH=4.0; 0.5 h; 3: With hydrogenchloride in water; acetonitrile T=20°C; 20 h; Product distribution / selectivity;
参考文献
FERMION OY
Patent: WO2006/82279 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: triethylamine; pyridine; acetamide / dichloromethane / 2 h / 30 - 40 °C / Inert atmosphere 2: hydrogenchloride / water View Scheme
参考文献
CADILA HEALTHCARE LIMITED
Patent: EP2341046 A2, 2011 ;
反应条件
potassium carbonate in acetone 6 h; Heating;
参考文献
Yaegashi; Nokata; Sawada; Furuta; Yokokura; Miyasaka
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 1 p. 131 - 135
