4-硝基-2,3,5-三甲基吡啶-N-氧化物合成路线 （共 16 条）
反应条件
sulfuric acid; nitric acid T=100°C; 24 h;
参考文献
CONFORMA THERAPEUTICS CORPORATION
Patent: WO2005/28434 A2, 2005 ;
Location in patent: Page/Page column 332 ;
反应条件
sulfuric acid; dihydrogen peroxide in acetic acid
反应条件
nitric acid in acetic acid T=80°C; 33 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 70 percent / mCPBA / CH2Cl2 / 0 - 20 °C 2: 97 percent / conc. H2SO4; HNO3 / 24 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 12 p. 2767 - 2778
反应条件
1: morpholine * HCl / dimethylformamide / 2 h / 150 °C 2: 80 percent / NMP, morpholine / 2 h / 190 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 32 p. 3733 - 3736
反应条件
2: 110 °C 3: aq. NaOH / methanol / Heating 4: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
2: 110 °C 3: aq. NaOH / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1777 - 1788
反应条件
1-methyl-pyrrolidin-2-one T=190°C; 4 h;
参考文献
Joiner, Karen A.; King, Frank D.
Tetrahedron Letters, 1987 , vol. 28, # 32 p. 3733 - 3736
反应条件
acetyl chloride T=-30 - 20°C; 4.33 h; Product distribution / selectivity;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 39 ;
反应条件
sodium hydroxide; thionyl chloride; acetic anhydride in ice-water; dichloromethane; acetic acid
参考文献
Cipla Limited
Patent: EP1085019 A1, 2001 ;
