4-甲氧基-3-甲基-2-吡啶甲醇合成路线 （共 11 条）
反应条件
sodium hydroxide in methanol T=25°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
1: 5 h / 120 °C 2: NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 3.1: 5 h / 120 °C 4.1: NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
sodium hydroxide; acetic anhydride 1.) 100 deg C, 3 h, 2.) 80 deg C, 3 h; Multistep reaction. Yields of byproduct given;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
反应条件
1.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 1.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 2.1: 5 h / 120 °C 3.1: NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
1: 53 percent / conc. H2SO4, 65percent HNO3 / 20 h / 95 °C 2: 99 percent / K2CO3 / 2 h / Heating 3: 4 h / 100 °C 4: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 2: 88 percent / NaOH / H2O / 3 h / 25 °C View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 2: 88 percent / NaOH / H2O / 3 h / 25 °C 3: 57 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / -15 - -10 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
thionyl chloride in dichloromethane T=25°C; 2 h;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
thionyl chloride in dichloromethane
2 h;
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
