2-氯甲基-3,5-二甲基-4-甲氧基吡啶盐酸盐合成路线 （共 19 条）
反应条件
thionyl chloride in dichloromethane T=20°C; 1 h;
参考文献
Garst, Michael E.; Dolby, Lloyd Jay; Esfandiari, Shervin; MacKenzie, Vivian Rose; Avey JR., Alfred Arthur; Muchmore, David Charles; Cooper, Geoffrey Kenneth; Malone, Thomas C.
Patent: US2005/38076 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
thionyl chloride in dichloromethane T=15 - 30°C; 1 h;
参考文献
WO2008/102145 A2, ;
Page/Page column 19-20 ;
反应条件
sodium hydroxide; thionyl chloride; sodium nitrite; nickel monoaluminide in NH3 -saturated methanol; water; acetic acid
反应条件
1: 110 °C 2: aq. NaOH / methanol / Heating 3: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1777 - 1788
反应条件
1: aq. NaOH / methanol / Heating 2: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1777 - 1788
反应条件
2: 110 °C 3: aq. NaOH / methanol / Heating 4: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1777 - 1788
反应条件
1: HNO3 / Heating 3: 110 °C 4: aq. NaOH / methanol / Heating 5: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1777 - 1788
反应条件
1: 76 percent / 30percent aq. H2O2, HOAc / 23 h / 90 °C 2: HNO3 / Heating 4: 110 °C 5: aq. NaOH / methanol / Heating 6: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1777 - 1788
反应条件
1: sodium hydroxide 2: acetic acid / methanol; toluene 3: sodium hydroxide / methanol 4: thionyl chloride View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
