2-(氯甲基)-4-甲氧基-3-甲基吡啶盐酸盐合成路线 （共 11 条）
反应条件
sodium hydroxide in water T=25°C; 3 h;
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1: 88 percent / NaOH / H2O / 3 h / 25 °C 2: 57 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / -15 - -10 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
thionyl chloride in dichloromethane
2 h;
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C
2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C
2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C
3.1: 5 h / 120 °C
4.1: NaOH / H2O / 1 h / 25 °C
5.1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1: 5 h / 120 °C
2: NaOH / H2O / 1 h / 25 °C
3: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1: NaOH / H2O / 1 h / 25 °C
2: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
反应条件
1: 53 percent / conc. H2SO4, 65percent HNO3 / 20 h / 95 °C
2: 99 percent / K2CO3 / 2 h / Heating
3: 4 h / 100 °C
4: 2 M NaOH / 1 h / 100 °C
5: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1.1: NaOH / dimethylsulfoxide / 1 h / 60 °C
1.2: 15 g / dimethylsulfoxide / 4 h / 60 °C
2.1: 5 h / 120 °C
3.1: NaOH / H2O / 1 h / 25 °C
4.1: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Pingili, R. Reddy; Jambula, M. Reddy; Ganta, M. Reddy; Ghanta, M. Reddy; Sajja; Sundaram; Boluggdu, V. Bhaskar
Pharmazie, 2005 , vol. 60, # 11 p. 814 - 818
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
参考文献
Byk Gulden Lomberg Chemische Fabrik Gesellschaft mit beschrankter Haftung
Patent: US4472409 A1, 1984 ;
