2-(3-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-基)乙酸甲酯合成路线 （共 9 条）
反应条件
water; sodium hydroxide in methanol T=20°C; 3 h;
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
Location in patent: Page/Page column 92 ;
反应条件
sodium hydrogencarbonate in water; ethyl acetate
T=25°C; 1 h;
参考文献
Gruenenthal GmbH
Patent: US2010/234340 A1, 2010 ;
Location in patent: Page/Page column 23 ;
US 20100234340 A1
反应条件
1: acetic acid; nitric acid; acetic anhydride / 2 h / -30 - 20 °C
2: boron tribromide / dichloromethane / 4 h / -70 - 20 °C
3: caesium carbonate / tetrahydrofuran / 2 h / 20 °C / |Reflux
4: acetic acid; iron / 2 h / |Reflux
View Scheme
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
反应条件
1: boron tribromide / dichloromethane / 4 h / -70 - 20 °C
2: caesium carbonate / tetrahydrofuran / 2 h / 20 °C / |Reflux
3: acetic acid; iron / 2 h / |Reflux
View Scheme
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
反应条件
1: caesium carbonate / tetrahydrofuran / 2 h / 20 °C / |Reflux
2: acetic acid; iron / 2 h / |Reflux
View Scheme
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
反应条件
1: thionyl chloride / 1.5 h / 0 °C / |Reflux
2: acetic acid; nitric acid; acetic anhydride / 2 h / -30 - 20 °C
3: boron tribromide / dichloromethane / 4 h / -70 - 20 °C
4: caesium carbonate / tetrahydrofuran / 2 h / 20 °C / |Reflux
5: acetic acid; iron / 2 h / |Reflux
View Scheme
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
反应条件
1: acetic acid; nitric acid / 1 h / 15 °C
2: thionyl chloride / 2 h / 0 - 20 °C
3: caesium carbonate / tetrahydrofuran / 2 h / 20 °C / |Reflux
4: acetic acid; iron / 2 h / |Reflux
View Scheme
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
反应条件
1: thionyl chloride / 2 h / 0 - 20 °C
2: caesium carbonate / tetrahydrofuran / 2 h / 20 °C / |Reflux
3: acetic acid; iron / 2 h / |Reflux
View Scheme
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
反应条件
iron; acetic acid
2 h; Reflux;
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
Location in patent: Page/Page column 91; 92 ;
