6-[(E)-2-(2,6,6-三甲基-1-环己烯-1-基)乙烯基]-2-萘甲酸合成路线 （共 3 条）
反应条件
potassium hydroxide in methanol; water
0.5 h; Heating;
参考文献
SRI International
Patent: US4456618 A1, 1984 ;
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 20 min, 2.) THF, RT, 24 h
2: 75 percent / KOH / methanol; H2O / 0.5 h / Heating
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca L.-S.; Derdzinski, Krzysztof; Hobbs, Peter D.; Chao, Wan-Ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1653 - 1656
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 20 min, 2.) THF, RT, 24 h
2: 75 percent / KOH / methanol; H2O / 0.5 h / Heating
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca L.-S.; Derdzinski, Krzysztof; Hobbs, Peter D.; Chao, Wan-Ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1653 - 1656
