反应条件
1: 1.) 50percent polyphosphoric acid / 1.) 130 deg C, 4 h, 2.) reflux, 18 h
2: 44.5 percent / 5 N aq. acetic acid / 4 h / Heating
3: 64 percent / MnO2 / diethyl ether / 2 h / Heating
4: 13 percent / pyridine hydrochloride / 3.5 h / 140 °C
5: 54 percent / NaBH4 / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Archer; Zayed; Rej; Rugino
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1240 - 1246