1-Boc-1,2,5,6-四氢吡啶-3-羧酸合成路线 （共 15 条）
反应条件
sodium hydroxide in methanol; water T=20°C; Hydrolysis; 15 h;
参考文献
Knapp; Zhao
Organic letters, 2000 , vol. 2, # 25 p. 4037 - 4040
反应条件
1: NaOH; MTBE / H2O 2: H2 / Ra-Ni / ethanol 3: Et3N / tetrahydrofuran 4: DBU / tetrahydrofuran 5: 98 percent / NaOH / H2O; methanol / 15 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 25 p. 4037 - 4040
反应条件
lithium hydroxide hydrate; water in tetrahydrofuran; methanol T=20°C; 4 h;
参考文献
Napolitano, Carmela; Borriello, Manuela; Cardullo, Francesca; Donati, Daniele; Paio, Alfredo; Manfredini, Stefano
Tetrahedron, 2010 , vol. 66, # 29 p. 5492 - 5497
反应条件
1: guvacine hydrochloride With sodium hydroxide in tert-butyl alcohol T=5 - 10°C; deprotonation; 2: di-tert-butyl dicarbonate in tert-butyl alcohol T=20°C; Substitution;
参考文献
Guo, Zhengming; Zheng, Xiaozhang; Thompson, Walter; Dugdale, Marion; Gollamudi, Ram
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1041 - 1058
反应条件
sodium hydroxide in tert-butyl alcohol T=45 - 50°C; 2 h;
参考文献
Allan; Fong
Australian Journal of Chemistry, 1983 , vol. 36, # 3 p. 601 - 608
反应条件
sodium hydroxide in ethanol
反应条件
1: NaOH; MTBE / H2O 2: H2 / Ra-Ni / ethanol 3: Et3N / tetrahydrofuran 4: DBU / tetrahydrofuran 5: 98 percent / NaOH / H2O; methanol / 15 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 25 p. 4037 - 4040
反应条件
1: H2 / Ra-Ni / ethanol 2: Et3N / tetrahydrofuran 3: DBU / tetrahydrofuran 4: 98 percent / NaOH / H2O; methanol / 15 h / 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 25 p. 4037 - 4040
反应条件
1: 83 percent / K2CO3 / benzene / 16 h / Heating 2: 1.) Zn, AcOH, 2.) 48percent aq. HBr / 1.) 30 deg C, 2h, 2.) reflux, 3h 3: 60 percent / NaOH / 2-methyl-propan-2-ol / 2 h / 45 - 50 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 36, # 3 p. 601 - 608
反应条件
1: 1.) Zn, AcOH, 2.) 48percent aq. HBr / 1.) 30 deg C, 2h, 2.) reflux, 3h 2: 60 percent / NaOH / 2-methyl-propan-2-ol / 2 h / 45 - 50 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 36, # 3 p. 601 - 608
