2'4'-二氟-2-[1-(1H-1,2,4-三唑基)]苯乙酮合成路线 （共 36 条）
反应条件
1: With lead; iodine; zinc in tetrahydrofuran T=5 - 25°C; Reformatsky Reaction; Inert atmosphere; 2: With hydrogenchloride in isopropyl alcohol T=25°C;
参考文献
DONGKOOK PHARMACEUTICAL CO., LTD.; KWON, Hyuk Chul; RHO, Man Dong; CHA, Kyung Hoi
Patent: WO2011/96697 A2, 2011 ;
Location in patent: Page/Page column 15-16 ;
反应条件
potassium hydroxide in tert-butyl alcohol Heating;
参考文献
Narayanan; Chapman; Upadhyaya; Bauer
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1405 - 1412
反应条件
sodium hydroxide in toluene T=80°C; Corey-Chaykovsky epoxidation; 0.833333 h; microwave irradiation;
参考文献
Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483
反应条件
sodium hydroxide in toluene T=60°C;
参考文献
Wang, Yan; Damu, Guri L.V.; Lv, Jing-Song; Geng, Rong-Xia; Yang, Da-Cheng; Zhou, Cheng-He
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5363 - 5366
反应条件
1: trimethylsulfoxonium iodide With sodium hydride in dimethyl sulfoxide 1 h; 2: 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one in dimethyl sulfoxide T=20°C; 12 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: WO2005/14583 A1, 2005 ;
Location in patent: Page/Page column 21-22 ;
反应条件
sodium hydroxide in toluene T=60°C; 3 h;
参考文献
Chai, Xiaoyun; Zhang, Jun; Hu, Honggang; Yu, Shichong; Sun, Qingyan; Dan, Zhigang; Jiang, Yuanying; Wu, Qiuye
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 1913 - 1920
反应条件
trimethylsulfoxonium iodide; cetylmonomethylammonium bromide; sodium hydroxide in toluene T=60°C; 3 h;
参考文献
Chai, Xiaoyun; Yu, Shichong; Jiang, Yongwei; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Cao, Yongbing; Sun, Qingyan
Archives of Pharmacal Research, 2012 , vol. 35, # 11 p. 1895 - 1901
参考文献
Itoh, Hiroyuki; Yoneda, Rieko; Tobitsuka, Junzo; Ohta, Hiroshi; Takahi, Yukiyoshi; Tsuda, Mikio; Takeshiba, Hideo
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1113 - 1116
反应条件
1: 4-chloro-6-ethyl-5-fluoropyrimidine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane; n-heptane T=-73 - 18°C; 2.25 h; 2: 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one in tetrahydrofuran; hexane; n-heptane T=-74 - 55°C; 5 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/65726 A2, 2006 ;
Location in patent: Page/Page column 17-18 ;
反应条件
diisopropylamine in tetrahydrofuran; water; acetic acid
参考文献
Pfizer Inc.
Patent: US5278175 A1, 1994 ;
