2'4'-二氟-2-[1-(1H-1,2,4-三唑基)]苯乙酮合成路线 （共 36 条）
反应条件
potassium carbonate in acetonitrile T=85°C; 0.833333 h; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 47, # 36 p. 6479 - 6483
反应条件
potassium carbonate in dichloromethane T=20°C; 24 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 45, # 12 p. 6020 - 6026
反应条件
1: AlCl3 2: anhydrous potassium carbonate / CHCl3 / Heating View Scheme
参考文献
Synthetic Communications, , vol. 37, # 2 p. 199 - 207
参考文献
Analytical Chemistry, , vol. 78, # 11 p. 3835 - 3838
反应条件
sodium hydroxide T=45°C; 14 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 9 p. 2625 - 2632
反应条件
triethylamine in acetone T=20°C; 0.5 h;
参考文献
Journal of Organometallic Chemistry, , vol. 691, # 12 p. 2686 - 2690
反应条件
1: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH2Cl2 / 48 h / -20 °C 2: 77 percent / dimethylsulfoxide; H2O / 3 h / 55 °C 3: Et3N / toluene / 0.5 h / 0 °C 4: 15percent aq. KOH / toluene / 2 h / 0 °C 5: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C 6: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C 7: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 9 p. 2625 - 2632
反应条件
1: 77 percent / dimethylsulfoxide; H2O / 3 h / 55 °C 2: Et3N / toluene / 0.5 h / 0 °C 3: 15percent aq. KOH / toluene / 2 h / 0 °C 4: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C 5: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C 6: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 9 p. 2625 - 2632
反应条件
1: 84 percent / H2O; dimethylsulfoxide / 3 h / 55 °C 2: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C 3: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 9 p. 2625 - 2632
反应条件
1: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C 2: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C 3: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 69, # 9 p. 2625 - 2632
