5-溴-n-异丙基-2-硝基苯胺合成路线 （共 5 条）
反应条件
sodium dithionite in ethanol; water T=20°C;
参考文献
GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun
Patent: WO2012/174312 A2, 2012 ;
Location in patent: Page/Page column 221-222 ;
WO 2012/174312 A2
反应条件
1: With tin(ll) chloride in ethanol T=70°C; 3 h; 2: With water; sodium carbonate in ethanol T=0°C; pH=10;
参考文献
SCHERING CORPORATION
Patent: WO2008/82487 A2, 2008 ;
Location in patent: Page/Page column 110 ;
WO 2008/082487 A2
反应条件
potassium carbonate in tetrahydrofuran
T=90°C; 6 h;
参考文献
GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun
Patent: WO2012/174312 A2, 2012 ;
Location in patent: Page/Page column 221 ;
WO 2012/174312 A2
反应条件
in butan-1-ol
T=117°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/80380 A1, 2005 ;
Location in patent: Page/Page column 23 ;
WO 2005/080380 A1
反应条件
in ethanol
3 h; Heating / reflux;
参考文献
SCHERING CORPORATION
Patent: WO2008/82487 A2, 2008 ;
Location in patent: Page/Page column 109-110 ;
WO 2008/082487 A2
