N1-(2-(吡咯烷-1-基)乙基)苯-1,4-二胺合成路线 （共 4 条）
反应条件
hydrazine; nickel in ethanol
T=65°C; 1 h;
参考文献
Allergan, Inc.
Patent: US2007/32478 A1, 2007 ;
Location in patent: Page/Page column 146 ;
US 20070032478 A1
反应条件
1: 86 percent / TEA; DBU / CH2Cl2 / 70 h
2: 125 mg / hydrazine hydrate / Pd/C / Heating
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: TEA / CH2Cl2 / 0.5 h / 0 - 20 °C
2: 86 percent / TEA; DBU / CH2Cl2 / 70 h
3: 125 mg / hydrazine hydrate / Pd/C / Heating
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: 36 percent / 3 h / 40 °C
2: TEA / CH2Cl2 / 0.5 h / 0 - 20 °C
3: 86 percent / TEA; DBU / CH2Cl2 / 70 h
4: 125 mg / hydrazine hydrate / Pd/C / Heating
View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
