(E)-N-(2-氯-6-甲基苯基)-3-乙氧基丙烯酰胺合成路线 （共 4 条）
反应条件
pyridine in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
Liu, Wukun; Zhou, Jinpei; Qi, Fan; Bensdorf, Kerstin; Li, Zhiyu; Zhang, Huibin; Qian, Hai; Huang, Wenlong; Cai, Xueting; Cao, Peng; Wellner, Anja; Gust, Ronald
Archiv der Pharmazie, 2011 , vol. 344, # 7 p. 451 - 458
反应条件
1: sodium hydroxide; water / 2 h / Reflux 2: thionyl chloride / 2 h / Reflux 3: pyridine / tetrahydrofuran / 20 °C View Scheme
参考文献
WO2010/144338 A1, ;
WO 2010/144338 A1
反应条件
1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-bromosuccinmide in 1,4-dioxane; water T=-10 - 22°C; 3 h; 2: thiourea in 1,4-dioxane; water T=100°C; 2 h; 3: With ammonia in 1,4-dioxane; water T=20 - 22°C;
参考文献
WO2008/76883 A2, ;
Page/Page column 53-54 ;
WO 2008/076883 A2
反应条件
1: N-bromosuccinmide; water / 1,4-dioxane / 3 h / -10 - 22 °C 2: 1,4-dioxane; water / 2 h / 80 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 344, # 7 p. 451 - 458
