N-苯甲酰基-5'-O-[二(4-甲氧基苯基)(苯基)甲基]-3'-脱氧胞苷合成路线 （共 33 条）
反应条件
1: 1.) hexamethyldisilazane, (NH4)2SO4, 2.) trimethylsilyl triflate / 1.) reflux, 1,2-dichloroethane, RT, 1.5 h
2: 72 percent / NaOEt / 24 h / Ambient temperature
3: 77 percent / methanol / 4 h / Heating
4: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 82 percent / NaOEt / 24 h / Ambient temperature
2: 77 percent / methanol / 4 h / Heating
3: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 72 percent / AIBN, Bu3SnH / toluene / 6 h / 80 °C
2: HCOOH / 2 h / 50 °C
3: pyridine / 2 h / Ambient temperature
4: 1.) hexamethyldisilazane, (NH4)2SO4, 2.) trimethylsilyl triflate / 1.) reflux, 1,2-dichloroethane, RT, 1.5 h
5: 72 percent / NaOEt / 24 h / Ambient temperature
6: 77 percent / methanol / 4 h / Heating
7: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
2: 82 percent / NaOEt / 24 h / Ambient temperature
3: 77 percent / methanol / 4 h / Heating
4: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 72 percent / NaOEt / 24 h / Ambient temperature
2: 77 percent / methanol / 4 h / Heating
3: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 67 percent / DMAP / acetonitrile / 20 h / Ambient temperature
2: AIBN, Bu3SnH / toluene / 6 h / 75 °C
3: TBAF / tetrahydrofuran / 1 h
4: 80 percent / pyridine / 20 h / Ambient temperature
5: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
6: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
7: 82 percent / NaOEt / 24 h / Ambient temperature
8: 77 percent / methanol / 4 h / Heating
9: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: AIBN, Bu3SnH / toluene / 6 h / 75 °C
2: TBAF / tetrahydrofuran / 1 h
3: 80 percent / pyridine / 20 h / Ambient temperature
4: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
5: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
6: 82 percent / NaOEt / 24 h / Ambient temperature
7: 77 percent / methanol / 4 h / Heating
8: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: AIBN, Bu3SnH / toluene / 6 h / 75 °C
2: TBAF / tetrahydrofuran / 1 h
3: 80 percent / pyridine / 20 h / Ambient temperature
4: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
5: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
6: 82 percent / NaOEt / 24 h / Ambient temperature
7: 77 percent / methanol / 4 h / Heating
8: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 65 percent / DMAP / acetonitrile / 20 h / Ambient temperature
2: AIBN, Bu3SnH / toluene / 3 h / 85 °C
3: TBAF / tetrahydrofuran / 4 h / 75 °C
4: 81 percent / ZnBr2 / CH2Cl2; methanol / 0.33 h
5: 80 percent / pyridine / 20 h / Ambient temperature
6: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
7: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
8: 82 percent / NaOEt / 24 h / Ambient temperature
9: 77 percent / methanol / 4 h / Heating
10: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: AIBN, Bu3SnH / toluene / 3 h / 85 °C
2: TBAF / tetrahydrofuran / 4 h / 75 °C
3: 81 percent / ZnBr2 / CH2Cl2; methanol / 0.33 h
4: 80 percent / pyridine / 20 h / Ambient temperature
5: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
6: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
7: 82 percent / NaOEt / 24 h / Ambient temperature
8: 77 percent / methanol / 4 h / Heating
9: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
