N-苯甲酰基-5'-O-[二(4-甲氧基苯基)(苯基)甲基]-3'-脱氧胞苷合成路线 （共 33 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane 1 h; Ambient temperature;
参考文献
Jung Kyeong Eun; Switzer
Journal of the American Chemical Society, 1994 , vol. 116, # 14 p. 6059 - 6061
反应条件
1H-tetrazole in acetonitrile T=20°C; 2 h;
参考文献
Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796
反应条件
tetrabutyl ammonium fluoride in ethanol
参考文献
Ogilvie, Kelvin K.; Hakimelahi, Gholam H.; Proba, Zbigniew A.; Usman, Nassim
Tetrahedron Letters, 1983 , vol. 24, # 9 p. 865 - 868
参考文献
Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796
反应条件
1.1: TMS-Cl / pyridine / 0.33 h / 20 °C
1.2: 82 percent / pyridine / 2 h / 20 °C
2.1: 85 percent / pyridine / 20 °C
View Scheme
参考文献
Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796
反应条件
1: 43 percent / DBU / acetonitrile / 15 h / Ambient temperature
2: 65 percent / DMAP / acetonitrile / 20 h / Ambient temperature
3: AIBN, Bu3SnH / toluene / 3 h / 85 °C
4: TBAF / tetrahydrofuran / 4 h / 75 °C
5: 81 percent / ZnBr2 / CH2Cl2; methanol / 0.33 h
6: 80 percent / pyridine / 20 h / Ambient temperature
7: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
8: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
9: 82 percent / NaOEt / 24 h / Ambient temperature
10: 77 percent / methanol / 4 h / Heating
11: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 52 percent / dimethylformamide / 4 h / Ambient temperature
2: 40 percent / 2,2'-azobis(2-methylpropionitrile), (n-Bu)3SnH / toluene / 4 h / Heating
3: 90 percent / TBAF / ethanol
View Scheme
参考文献
Ogilvie, Kelvin K.; Hakimelahi, Gholam H.; Proba, Zbigniew A.; Usman, Nassim
Tetrahedron Letters, 1983 , vol. 24, # 9 p. 865 - 868
反应条件
1: 40 percent / 2,2'-azobis(2-methylpropionitrile), (n-Bu)3SnH / toluene / 4 h / Heating
2: 90 percent / TBAF / ethanol
View Scheme
参考文献
Ogilvie, Kelvin K.; Hakimelahi, Gholam H.; Proba, Zbigniew A.; Usman, Nassim
Tetrahedron Letters, 1983 , vol. 24, # 9 p. 865 - 868
反应条件
1: 50 percent / DBU / acetonitrile / 2 h / Ambient temperature
2: 81 percent / DMAP / acetonitrile / 20 h / Ambient temperature
3: AIBN, Bu3SnH / toluene / 6 h / 75 °C
4: TBAF / tetrahydrofuran / 1 h
5: 80 percent / pyridine / 20 h / Ambient temperature
6: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
7: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
8: 82 percent / NaOEt / 24 h / Ambient temperature
9: 77 percent / methanol / 4 h / Heating
10: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1.1: TMS-Cl / pyridine / 0.33 h / 20 °C
1.2: 82 percent / pyridine / 2 h / 20 °C
2.1: 85 percent / pyridine / 20 °C
View Scheme
参考文献
Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796
