2-(对氟苯基)-4-苯基吡咯合成路线 （共 5 条）
反应条件
copper diacetate in ethanol; dimethyl sulfoxide
T=110°C; 4 h; Inert atmosphereSchlenk technique; regioselective reaction;
参考文献
Chen, Feng; Shen, Tao; Cui, Yuxin; Jiao, Ning
Organic Letters, 2012 , vol. 14, # 18 p. 4926 - 4929,4
反应条件
1.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C
1.2: H2SO4 / tetrahydrofuran / 1 h / 20 °C
2.1: 0.31 g / AcOH; NH4OAc / 1 h / 100 °C
View Scheme
参考文献
Hall, Michael J.; McDonnell, Shane O.; Killoran, John; O'Shea, Donal F.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5571 - 5578
反应条件
1.1: 93 percent / Et2NH / methanol / 16 h / Heating
2.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C
2.2: H2SO4 / tetrahydrofuran / 1 h / 20 °C
3.1: 0.31 g / AcOH; NH4OAc / 1 h / 100 °C
View Scheme
参考文献
Hall, Michael J.; McDonnell, Shane O.; Killoran, John; O'Shea, Donal F.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5571 - 5578
反应条件
1.1: 98 percent / KOH / ethanol; H2O
2.1: 93 percent / Et2NH / methanol / 16 h / Heating
3.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C
3.2: H2SO4 / tetrahydrofuran / 1 h / 20 °C
4.1: 0.31 g / AcOH; NH4OAc / 1 h / 100 °C
View Scheme
参考文献
Hall, Michael J.; McDonnell, Shane O.; Killoran, John; O'Shea, Donal F.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5571 - 5578
反应条件
1.1: 98 percent / KOH / ethanol; H2O
2.1: 93 percent / Et2NH / methanol / 16 h / Heating
3.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C
3.2: H2SO4 / tetrahydrofuran / 1 h / 20 °C
4.1: 0.31 g / AcOH; NH4OAc / 1 h / 100 °C
View Scheme
参考文献
Hall, Michael J.; McDonnell, Shane O.; Killoran, John; O'Shea, Donal F.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5571 - 5578
