1: With n-butyllithium; N,N-dicyclohexylamine in toluene T=0 - 20°C; 0.25 h; 2: 2-methylpropanoic acid methyl ester in toluene T=20°C; 0.25 h; 3: ortho-fluorobromobenzene With [(t-Bu)3PH]BF4; bis(dibenzylideneacetone)-palladium(0) in toluene T=20°C; 18 h;

18-crown-6 ether; potassium tert-butylate; sodium hydride in tetrahydrofuran T=20°C; 36 h;

1: 2-methylpropanoic acid methyl ester With LiN(Cy)2 in toluene T=20°C; 0.25 h; Inert atmosphere; 2: ortho-fluorobromobenzene With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in toluene T=50°C; 2 h; Inert atmosphere;

1: With potassium hydroxide; ethanol; water T=130°C; 2 h; 2: With hydrogenchloride; water pH=1;