3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
potassium carbonate in methanol
参考文献
Demchuk, Dmitry V.; Samet, Alexander V.; Chernysheva, Natalia B.; Ushkarov, Vladimir I.; Stashina, Galina A.; Konyushkin, Leonid D.; Raihstat, Mikhail M.; Firgang, Sergei I.; Philchenkov, Alex A.; Zavelevich, Michael P.; Kuiava, Ludmila M.; Chekhun, Vasyl F.; Blokhin, Dmitry Yu.; Kiselyov, Alex S.; Semenova, Marina N.; Semenov, Victor V.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 738 - 755
反应条件
1: diazomethyl-trimethyl-silane With lithium diisopropyl amide in various solvents
T=-78°C; 1 h;
2: 3,4,5-trimethoxy-benzaldehyde in various solvents
T=-78 - 20°C; 3 h; Further stages.;
参考文献
Odlo, Kristin; Fournier-Dit-Chabert, Jeremie; Ducki, Sylvie; Gani, Osman A.B.S.M.; Sylte, Ingebrigt; Hansen, Trond Vidar
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6874 - 6885
反应条件
1: PPh3 / CH2Cl2 / 0.08 h / 0 °C
2: 0.770 g / n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
View Scheme
参考文献
Lawrence, Nicholas J.; Ghani, Fazni Abdul; Hepworth, Lucy A.; Hadfield, John A.; McGown, Alan T.; Pritchard, Robin G.
Synthesis, 1999 , # 9 p. 1656 - 1660
反应条件
1: With triphenylphosphine in dichloromethane
T=0°C;
2: With n-butyllithium in tetrahydrofuran
参考文献
Mahoney, Stuart J.; Moon, David T.; Hollinger, Jon; Fillion, Eric
Tetrahedron Letters, 2009 , vol. 50, # 33 p. 4706 - 4709
反应条件
1: benzene / 4 h / Reflux; Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux
View Scheme
参考文献
Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh
Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2124 - 2133
反应条件
1: 1) n-BuLi / 1) ether, THF, -78 deg C, 15 min, 2) THF, -78 deg C, 30 min
2: 1) DDQ, 2) 2 N H2SO4 / 1) benzene, r.t., 4 h, 2) r.t., 3 h
View Scheme
参考文献
Patil, P. A.; Joshi, R. R.; Narasimhan, N. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 1025 - 1029
反应条件
1: piperidine / pyridine
2: aq. NaHCO3 / Irradiation
3: (i), (ii) H2, Pd-C, AcOH
View Scheme
参考文献
Cooper,P.D.
Canadian Journal of Chemistry, 1970 , vol. 48, p. 3882 - 3888
反应条件
piperidine; pyridine in ethanol
18 h; Heating / reflux;
参考文献
Zaveri, Nurulain; Chao, Wan-Ru
Patent: US2003/229136 A1, 2003 ;
Location in patent: Page 16-17 ;
反应条件
pyridine in ethanol; dichloromethane; water; ethyl acetate
参考文献
Zaveri, Nurulain; Chao, Wan-Ru
Patent: US2004/29914 A1, 2004 ;
反应条件
1: 80 percent / piperidine; H2O / 48 h / Heating
2: 89 percent / piperidine / pyridine / 6 h / 120 °C
View Scheme
参考文献
Ren, Xinfeng; Chen, Xiaochuan; Peng, Kun; Xie, Xingang; Xia, Yamu; Pan, Xinfu
Tetrahedron Asymmetry, 2002 , vol. 13, # 16 p. 1799 - 1804
