3,4,5-三甲氧基苯甲醛合成路线 （共 427 条）
反应条件
sodium hydroxide in ethanol
T=0 - 20°C; Claisen-Schmidt condensation;
参考文献
Bandgar, Babasaheb P.; Gawande, Shrikant S.; Bodade, Ragini G.; Totre, Jalinder V.; Khobragade, Chandrahas N.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1364 - 1370
反应条件
toluene-4-sulfonic acid in dichloromethane
参考文献
Inayama,S. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 433 - 436
反应条件
sodium hydroxide in ethanol; water
T=20°C; Aldol Condensation;
参考文献
Dias, Tatiana A.; Duarte, Cecilia L.; Lima, Cristovao F.; Proenca, M. Fernanda; Pereira-Wilson, Cristina
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 500 - 510
反应条件
sodium hydroxide in ethanol
T=0 - 20°C; Claisen-Schmidt condensation;
参考文献
Bandgar, Babasaheb P.; Gawande, Shrikant S.; Bodade, Ragini G.; Totre, Jalinder V.; Khobragade, Chandrahas N.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1364 - 1370
反应条件
sodium hydroxide in methanol
Claisen Schmidt condensation; Cooling;
参考文献
Batovska, Daniela; Parushev, Stoyan; Stamboliyska, Bistra; Tsvetkova, Iva; Ninova, Mariana; Najdenski, Hristo
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2211 - 2218
反应条件
1: 97 percent / H2 / 10percent Pd/C / acetic acid / 72 h / 30002.4 Torr / Ambient temperature
2: 96 percent / 57percent HI, 30percent aq. H3PO2 / Heating
3: 82 percent / molecular sieves 4 Angstroem / Amberlite IR 120-plus / benzene / Heating
4: K2CO3 / Bu4NHSO4 / acetone / 24 h / Heating
5: TsOH / methanol; H2O / 16 h / Ambient temperature
6: 91 percent / K2CO3 / acetone / 15 h / Heating
7: 96 percent / H2 / 10percent Pd/C / tetrahydrofuran / 6 h / Ambient temperature
8: 92 percent / K2(SO3)2NO, KH2SO4 / benzene; H2O / 3 h / Ambient temperature
9: 100 percent / CH2Cl2 / 96 h / Ambient temperature
10: 1.) KOBu-t / 1.) Et2O, -40 deg C, 30 min, 2.) Et2O, -70 deg C to room temp.
11: 100 percent / 3 h / 80 °C / 7.5 Torr
View Scheme
参考文献
Merz; Rauschel
Synthesis, 1993 , # 8 p. 797 - 802
反应条件
1: hydroxylamine hydrochloride, sodium hydroxide / aq. ethanol; H2O / Ambient temperature
2: acetic anhydride / Heating
3: hydrogen sulphide gas, triethylamine, pyridine / Ambient temperature
View Scheme
参考文献
Khadse, B. G.; Lokhande, S. R.; Bhamaria, R. P.; Prabhu, S. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 856 - 860
反应条件
1: NaBH4 / methanol / 20 °C
2: PBr3 / diethyl ether / -40 °C
3: benzene / 20 °C
View Scheme
参考文献
Olszewski; Marshalla; Sabat; Sundberg
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4285 - 4296
反应条件
1: 3,4,5-trimethoxy-benzaldehyde With sodium tetrahydroborate in ethanol
T=20°C; 2 h;
2: dibromotriphenyl-phosphorane in acetonitrile
T=90°C; 6 h;
参考文献
Das, Bhaskar C.; Mahalingam, Sakkarapalayam M.; Evans, Todd
Tetrahedron Letters, 2009 , vol. 50, # 25 p. 3031 - 3034
反应条件
1: Ac2O, AcONa / 4 h / 100 °C
2: 1.) 1.0 N aq. NaOH, 2.) aq. HCl / 1.) steam bath, 2.) reflux, 4 h
View Scheme
参考文献
Shaw; Srivastava; Jha
Journal of the Indian Chemical Society, 1990 , vol. 67, # 2 p. 144 - 147
