2,3-二甲氧基苯甲醛合成路线 （共 174 条）
反应条件
[bpy]Cl*AlCl3
Knoevenagel condensation; 0.0833333 h;
参考文献
Harjani, Jitendra R; Nara, Susheel J; Salunkhe, Manikrao M
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1127 - 1130
反应条件
1: AcOH / ethanol / 18 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 91 percent / acetic anhydride / 1 h / 70 °C
4: 92 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature
5: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 1 h
6: 80 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
7: 94 percent / 10percent aq. NaOH / ethanol / Ambient temperature
View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: ammonium acetate; acetic acid / 12 h / 100 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C
3: hydrogenchloride / water / 1 h / 60 °C
4: hydrogenchloride / water; tert-butyl methyl ether / 18 h / 20 °C
5: sodium hydrogencarbonate / water / 0.5 h / 20 °C
View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
反应条件
1: ammonium acetate; acetic acid / 12 h / 100 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C
3: hydrogenchloride / water / 1 h / 60 °C
4: hydrogenchloride / water; tert-butyl methyl ether / 18 h / 20 °C
View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
