2-氯-4-氟苯甲酸甲酯合成路线 （共 17 条）
反应条件
1: 85 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 5 h / 120 °C 2: 100 percent / 6 N aq. HCl; AcOH / 4 h / Heating View Scheme
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397
反应条件
1: copper (I) cyanide / 1-methyl-pyrrolidin-2-one / 1.5 h / 195 °C / Inert atmosphere 2: hydrogen; nickel / ethanol / 16 h / 2585.81 Torr / Inert atmosphere View Scheme
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
WO 2012/031004 A1
反应条件
1: 78 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 5 h / 120 °C 2: 98 percent / 5 N aq. NaOH / methanol / 15 h / Heating View Scheme
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397
反应条件
1: 76 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 5 h / 120 °C 2: 53 percent / 5 N aq. NaOH / methanol / 15 h / Heating View Scheme
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397
反应条件
1-methyl-pyrrolidin-2-one; potassium carbonate T=120°C; 3 h;
参考文献
Tsukamoto, Issei; Koshio, Hiroyuki; Akamatsu, Seijiro; Kuramochi, Takahiro; Saitoh, Chikashi; Yatsu, Takeyuki; Yanai-Inamura, Hiroko; Kitada, Chika; Yamamoto, Eisaku; Sakamoto, Shuichi; Tsukamoto, Shin-ichi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 21 p. 9524 - 9535
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran T=65°C; 3.5 h;
参考文献
Boechat, Nubia; Santos Da Costa, Jorge Carlos; De Souza Mendonca, Jorge; Mello De Oliveira, Pedro Santos; Nora De Souza, Marcus Vinicius
Tetrahedron Letters, 2004 , vol. 45, # 31 p. 6021 - 6022
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one T=120°C; 5 h;
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397
