5-溴-1-三异丙基硅烷-1H-吡咯并[2,3-b]吡啶合成路线 （共 7 条）
反应条件
1: 5-Bromo-1H-pyrrolo[2,3-b]pyridine With sodium hydride in tetrahydrofuran T=20°C; 0.25 h; 2: triisopropylsilyl chloride in tetrahydrofuran T=80°C; 3 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 180 ;
WO 2005/103050 A2
反应条件
1: 5-Bromo-1H-pyrrolo[2,3-b]pyridine With sodium hydride in 1,4-dioxane; N,N-dimethyl-formamide 0.5 h; 2: triisopropylsilyl chloride in 1,4-dioxane; N,N-dimethyl-formamide T=20°C;
参考文献
NERVIANO MEDICAL SCIENCES S.r.l.
Patent: EP2070928 A1, 2009 ;
Location in patent: Page/Page column 101-102 ;
EP 2070928 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran; hexane 3 h;
参考文献
PLEXXIKON, INC.
Patent: WO2007/2325 A1, 2007 ;
Location in patent: Page/Page column 105 ;
WO 2007/002325 A1
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; 0.0333333 h;
2: With boric acid trimethyl ester in tetrahydrofuran
T=-78 - 20°C; 1 h;
参考文献
ABBOTT LABORATORIES; TAO, Zhi-Fu; WANG, Xilu; SOUERS, Andrew J.; CATRON, Nathaniel D.; SULLIVAN, Gerard
Patent: WO2011/150016 A1, 2011 ;
Location in patent: Page/Page column 80 ;
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; 1.16667 h;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran
T=-78°C; 2 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/103050 A2, 2005 ;
Location in patent: Page/Page column 180-189 ;
WO 2005/103050 A2
反应条件
1: 5-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine With tert.-butyl lithium in tetrahydrofuran
T=-78°C; 0.333333 h;
2: acetone in tetrahydrofuran
T=-78 - 20°C; 0.5 h;
3: With water in tetrahydrofuran
T=20°C;
参考文献
PLEXXIKON, INC.
Patent: WO2007/2325 A1, 2007 ;
Location in patent: Page/Page column 113-114 ;
WO 2007/002325 A1
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran; toluene
T=90°C; 2 h;
参考文献
PLEXXIKON, INC.
Patent: WO2007/2325 A1, 2007 ;
Location in patent: Page/Page column 114-115 ;
WO 2007/002325 A1
