2-甲基噁唑-4-甲酸甲酯合成路线 （共 13 条）
反应条件
trichloromonobromomethane; 1,5-diazabicyclolt;5.3.0gt;undecane in dichloromethane T=0°C; 6 h;
参考文献
Williams, David R.; Lowder, Patrick D.; Gu, Yu-Gui; Brooks, Dawn A.
Tetrahedron Letters, 1997 , vol. 38, # 3 p. 331 - 334
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(ll) bromide T=20°C; 2 h;
参考文献
Lafontaine, Jennifer A.; Provencal, David P.; Gardelli, Cristina; Leahy, James W.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4215 - 4234
反应条件
1: NaOMe / TBAB / dimethylformamide / Ambient temperature 2: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 16 h, 2.) 5 h 3: K2CO3, ClCH2COOH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 21 p. 5759 - 5764
反应条件
1: With triethylamine in dichloromethane 5.5 h; Heating; 2: With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrachloromethane; acetonitrile T=20°C; 18 h; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 18 p. 3878 - 3890
反应条件
1: 1.) NCS, 2.) EtN(i-Pr)2 / 1.) DMF, r.t., 16 h, 2.) 5 h 2: K2CO3, ClCH2COOH / methanol / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 21 p. 5759 - 5764
反应条件
1: t-BuOK / tetrahydrofuran / -10 °C 2: AcOH View Scheme
参考文献
Tetrahedron Letters, , vol. 22, # 33 p. 3163 - 3166
参考文献
Tetrahedron Letters, , vol. 22, # 33 p. 3163 - 3166
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 51, # 26 p. 5111 - 5123
反应条件
diisobutylaluminium hydride in dichloromethane T=-78°C; 3 h; Inert atmosphere;
参考文献
Hobson, Stephen J.; Parkin, Andrew; Marquez, Rodolfo
Organic Letters, 2008 , vol. 10, # 13 p. 2813 - 2816
反应条件
1: With methanol; lithium hydroxide; water in tetrahydrofuran T=20°C; 2 h; 2: With hydrogenchloride in water pH=4;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 62 ;
