4-(4-溴苯基)-4-(4-氯苯基)哌啶合成路线 （共 3 条）
反应条件
aluminium trichloride
T=0°C; 2 h;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2007/125315 A2, 2007 ;
Location in patent: Page/Page column 128-129 ;
WO 2007/125315 A2
反应条件
1: With AlCl3, aluminium chloride
T=0°C; 4 h; Inert atmosphere;
2: With lithium hydroxide hydrate in water
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2009/89462 A1, 2009 ;
Location in patent: Page/Page column 60 ;
WO 2009/089462 A1
反应条件
aluminium chloride in chlorobenzene
参考文献
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: US2010/166699 A1, 2010 ;
