3-甲基2H-呋喃并[2,3-c]吡喃-2-酮合成路线 （共 36 条）
反应条件
toluene-4-sulfonic acid in toluene
1 h; Reflux;
参考文献
Matsuo, Kazumasa; Shindo, Mitsuru
Tetrahedron, 2011 , vol. 67, # 5 p. 971 - 975
反应条件
sodium acetate; acetic anhydride; triphenylphosphine
T=140°C; 0.583333 h;
参考文献
BOTANICAL GARDENS AND PARKS AUTHORITY; MURDOCH UNIVERSITY; THE UNIVERSITY OF WESTERN AUSTRALIA
Patent: WO2005/61515 A1, 2005 ;
Location in patent: Page/Page column 47 ;
反应条件
potassium phosphate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in toluene
参考文献
Sun, Kingmo; Chen, Yuzhong; Wagerle, Ty; Linnstaedt, David; Currie, Martin; Chmura, Preston; Song, Ying; Xu, Ming
Tetrahedron Letters, 2008 , vol. 49, # 18 p. 2922 - 2925
反应条件
aluminium trichloride in dichloromethane
0.5 h; Heating;
参考文献
Goddard-Borger, Ethan D.; Ghisalberti, Emilio L.; Stick, Robert V.
European Journal of Organic Chemistry, 2007 , # 23 p. 3925 - 3934
反应条件
sodium acetate
T=120°C; 3 h;
参考文献
BOTANICAL GARDENS AND PARKS AUTHORITY; MURDOCH UNIVERSITY; THE UNIVERSITY OF WESTERN AUSTRALIA
Patent: WO2005/61515 A1, 2005 ;
Location in patent: Page/Page column 45-46 ;
反应条件
n-butyllithium in tetrahydrofuran
T=-78°C;
参考文献
Sun, Kingmo; Chen, Yuzhong; Wagerle, Ty; Linnstaedt, David; Currie, Martin; Chmura, Preston; Song, Ying; Xu, Ming
Tetrahedron Letters, 2008 , vol. 49, # 18 p. 2922 - 2925
反应条件
1: 83 percent / aq. trifluoroacetic acid / CH2Cl2 / 0.08 h / 20 °C
2: 95 percent / pyridine / 2 h
3: 94 percent / triethylamine / CH2Cl2 / 0.08 h / 20 °C
4: 61 percent / tetrakis(triphenylphosphane)palladium(0) / tetrahydrofuran / 48 h / Heating
5: 92 percent / phosphoryl chloride / 0.25 h / 50 °C
6: 83 percent / aluminum(III) chloride; tBuNH2-BH3 / CH2Cl2 / 0.5 h / Heating
View Scheme
参考文献
Goddard-Borger, Ethan D.; Ghisalberti, Emilio L.; Stick, Robert V.
European Journal of Organic Chemistry, 2007 , # 23 p. 3925 - 3934
反应条件
1: 95 percent / pyridine / 2 h
2: 94 percent / triethylamine / CH2Cl2 / 0.08 h / 20 °C
3: 61 percent / tetrakis(triphenylphosphane)palladium(0) / tetrahydrofuran / 48 h / Heating
4: 92 percent / phosphoryl chloride / 0.25 h / 50 °C
5: 83 percent / aluminum(III) chloride; tBuNH2-BH3 / CH2Cl2 / 0.5 h / Heating
View Scheme
参考文献
Goddard-Borger, Ethan D.; Ghisalberti, Emilio L.; Stick, Robert V.
European Journal of Organic Chemistry, 2007 , # 23 p. 3925 - 3934
反应条件
1: 74 percent / tetrahydrofuran / 0.25 h / -10 °C
2: 83 percent / aq. trifluoroacetic acid / CH2Cl2 / 0.08 h / 20 °C
3: 95 percent / pyridine / 2 h
4: 94 percent / triethylamine / CH2Cl2 / 0.08 h / 20 °C
5: 61 percent / tetrakis(triphenylphosphane)palladium(0) / tetrahydrofuran / 48 h / Heating
6: 92 percent / phosphoryl chloride / 0.25 h / 50 °C
7: 83 percent / aluminum(III) chloride; tBuNH2-BH3 / CH2Cl2 / 0.5 h / Heating
View Scheme
参考文献
Goddard-Borger, Ethan D.; Ghisalberti, Emilio L.; Stick, Robert V.
European Journal of Organic Chemistry, 2007 , # 23 p. 3925 - 3934
反应条件
1: 95 percent / triethylamine / CH2Cl2 / 0.08 h / 20 °C
2: 84 percent / tetrakis(triphenylphosphane)palladium(0) / tetrahydrofuran / 8 h / Heating
3: 92 percent / phosphoryl chloride / 0.25 h / 50 °C
4: 83 percent / aluminum(III) chloride; tBuNH2-BH3 / CH2Cl2 / 0.5 h / Heating
View Scheme
参考文献
Goddard-Borger, Ethan D.; Ghisalberti, Emilio L.; Stick, Robert V.
European Journal of Organic Chemistry, 2007 , # 23 p. 3925 - 3934
