(5S)-N-[3-(4-溴-3-氟苯基)-2-氧代-5-恶唑烷基甲基]乙酰胺合成路线 （共 5 条）
反应条件
1: C10H8BrFN4O2 With iron; ammonium chloride in ethanol; water 12 h; Reflux; 2: acetic anhydride T=20°C; 1 h;
参考文献
LegoChem Biosciences, Inc.; CHO, Young Lag; BAEK, Sung Yoon; CHAE, Sang Eun; KIM, Sun Young; LEE, Hong Bum; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu
Patent: EP2692727 A2, 2014 ;
Location in patent: Paragraph 0178-0179 ;
反应条件
pyridine T=0 - 20°C; 2 h;
参考文献
LEGOCHEM BIOSCIENCE LTD.
Patent: WO2008/69619 A1, 2008 ;
Location in patent: Page/Page column 18; 21; 23-24 ;
反应条件
1.1: sodium hydroxide / dichloromethane / 1 h / 20 °C 2.1: lithium tert-butylate / N,N-dimethyl-formamide; methanol; tetrahydrofuran / 3 h / 0 - 20 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C 4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C 5.1: iron; ammonium chloride / water; ethanol / 12 h / |Reflux 5.2: 1 h / 20 °C View Scheme
反应条件
1.1: lithium tert-butylate / N,N-dimethyl-formamide; methanol; tetrahydrofuran / 3 h / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C 4.1: iron; ammonium chloride / water; ethanol / 12 h / |Reflux 4.2: 1 h / 20 °C View Scheme
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C 2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C 3.1: iron; ammonium chloride / water; ethanol / 12 h / |Reflux 3.2: 1 h / 20 °C View Scheme
