1: 4-cyanotetrahydro-4H-pyran With lithium hexamethyldisilazane in tetrahydrofuran T=0 - 5°C; 1.5 h; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; 2.5 h; 3: With hydrogenchloride in tetrahydrofuran; water; ethyl acetate T=0°C;

1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2: With water; sodium hydroxide in tetrahydrofuran 0.5 h;