3-(2-氯乙基)-N-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺合成路线 （共 5 条）
反应条件
sodium nitrite in water; acetic acid; ethyl acetate
参考文献
Cancer Research Campaign Technology Limited
Patent: US5260291 A1, 1993 ;
US 5260291 A
反应条件
1: 54 percent / H2 / palladium on charcoal (10percent)
2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating
3: 57 percent / tetrahydrofuran; H2O / 0.5 h
View Scheme
参考文献
Horspool, K. R.; Stevens, M. F. G.; Newton, C. G.; Lunt, E.; Walsh, R. J. A.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1393 - 1399
反应条件
in tetrahydrofuran; water
0.5 h;
参考文献
Horspool, K. R.; Stevens, M. F. G.; Newton, C. G.; Lunt, E.; Walsh, R. J. A.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1393 - 1399
反应条件
1: 77 percent / concd. sulfuric acid, sodium nitrite / H2O / 2.5 h / 35 °C
2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating
3: 57 percent / tetrahydrofuran; H2O / 0.5 h
View Scheme
参考文献
Horspool, K. R.; Stevens, M. F. G.; Newton, C. G.; Lunt, E.; Walsh, R. J. A.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1393 - 1399
反应条件
in ethyl acetate
24 h; Ambient temperature; Yield given;
参考文献
Lunt, Edward; Newton, Christopher G.; Smith, Christopher; Stevens, Graham P.; Stevens, Malcolm F. G.; et al.
Journal of Medicinal Chemistry, 1987 , vol. <2> 30, p. 357 - 366
