1: nortemozolomide With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.05 h; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 2.5 h;
1: With acetic acid; lithium bromide in water T=20°C; 1 h; 2: With sodium nitrite in water T=-10 - 20°C; 6 h; 3: With sodium thiosulfate in water 0.333333 h; Product distribution / selectivity;