5-(苄氧基)-2-溴苯甲醛合成路线 （共 7 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Kim, Myung Hee; Choi, Young Lok; Heo, Jung-Nyoung; Min, Yong Ki; Kim, Seong Hwan
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 7 p. 2047 - 2050
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 2 h;
参考文献
Lin, Jinshun; Zhang, Weige; Jiang, Nan; Niu, Zeyu; Bao, Kai; Zhang, Liang; Liu, Dailin; Pan, Chao; Yao, Xinsheng
Journal of Natural Products, 2008 , vol. 71, # 11 p. 1938 - 1941
反应条件
bromine; sodium acetate in acetic acid
T=0 - 20°C; 16 h;
参考文献
N.V. ORGANON
Patent: WO2009/37220 A1, 2009 ;
Location in patent: Page/Page column 52 ;
WO 2009/037220 A1
反应条件
bromine; sodium acetate in dichloromethane
5.75 h; Cooling with iceInert atmosphere;
参考文献
Huang, Shenlin; Petersen, Tue B.; Lipshutz, Bruce H.
Journal of the American Chemical Society, 2010 , vol. 132, # 40 p. 14021 - 14023
反应条件
1: 73 percent / Br2 / CHCl3 / 3 h / Ambient temperature
2: 74 percent / NaH / tetrahydrofuran; dimethylformamide / Ambient temperature
View Scheme
参考文献
Harmata, Michael; Kahraman, Mehmet
Journal of Organic Chemistry, 1999 , vol. 64, # 13 p. 4949 - 4952
反应条件
1: meta-hydroxybenzaldehyde With bromine in tetrachloromethane
2: benzyl bromide With potassium carbonate in N,N-dimethyl-formamide
T=60°C; Further stages.;
参考文献
Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5091 - 5094
反应条件
1: 44 percent / aq. HBr; AcOH / 3 h / 100 °C
2: K2CO3
View Scheme
参考文献
Claudi, Francesco; Di Stefano, Antonio; Napolitani, Fabrizio; Cingolani, Gian Mario; Giorgioni, Gianfabio; Fontenla, Jose A.; Montenegro, Gisela Y.; Rivas, Maria E.; Rosa, Elizabeth; Michelotto, Barbara; Orlando, Giustino; Brunetti, Luigi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 599 - 608
