4-溴-3-甲基-2-硝基苯酚合成路线 （共 10 条）
反应条件
1: 100 percent / K2CO3 / Heating 2: pyrrolidine / dimethylformamide / 14 h / 110 °C 3: NH2NH2*H2O; Raney-Ni / methanol; tetrahydrofuran View Scheme
参考文献
MERCK SHARP and DOHME CORP.; COBURN, Craig, A.; ROSENBLUM, Stuart, B.; KOZLOWSKI, Joseph, A.; SOLL, Richard; WU, Hao; HU, Bin; ZHONG, Bin; WANG, Dahai; SHEN, Changmao; SUN, Fei
Patent: WO2012/122716 A1, 2012 ;
反应条件
bromine in acetic acid
T=0°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; CARSON, Rebekah J.; FADER, Lee; KAWAI, Stephen; LANDRY, Serge
Patent: WO2009/62288 A1, 2009 ;
Location in patent: Page/Page column 60-61 ;
反应条件
nitric acid; acetic acid in water
参考文献
Sumitomo Pharmaceutical Co., Ltd.
Patent: US6169107 A, 2001 ;
US 6169107 B1
反应条件
1.1: H2SO4 (98 percent) / 26 h / 20 °C
1.2: 59 percent / HNO3; H2SO4 / 2 h / 0 °C
2.1: 98 percent / Br2 / acetic acid / 6 h
View Scheme
参考文献
Yang, Cai-Guang; Wang, Jun; Jiang, Biao
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1063 - 1066
反应条件
acetic acid
beim Nitrieren;
参考文献
Gibbs; Robertson
Journal of the Chemical Society, 1914 , vol. 105, p. 1891
反应条件
1: glacial acetic acid / durch Bromieren
2: acetic acid / beim Nitrieren
View Scheme
参考文献
Gibbs; Robertson
Journal of the Chemical Society, 1914 , vol. 105, p. 1891
参考文献
Gibbs; Robertson
Journal of the Chemical Society, 1914 , vol. 105, p. 1891
反应条件
potassium carbonate
Heating;
参考文献
Yang, Cai-Guang; Wang, Jun; Jiang, Biao
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 1063 - 1066
反应条件
sodium hydroxide in water
Heating;
参考文献
Cannon; Lukszo; Max
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 149 - 153
反应条件
1: 81.2 g / NaOH / H2O / Heating
2: iron fillings / benzene / Heating
View Scheme
参考文献
Cannon; Lukszo; Max
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 149 - 153
