2-羟基-2-邻甲苯乙酸合成路线 （共 11 条）
反应条件
sulfuric acid; hydrogen bromide in water 3 h; Heating;
参考文献
Guieysse, David; Salagnad, Christophe; Monsan, Pierre; Remaud-Simeon, Magali
Tetrahedron Asymmetry, 2003 , vol. 14, # 3 p. 317 - 323
反应条件
hydrogenchloride in water
T=20°C; 12 h;
参考文献
Guieysse, David; Salagnad, Christophe; Monsan, Pierre; Remaud-Simeon, Magali
Tetrahedron Asymmetry, 2003 , vol. 14, # 3 p. 317 - 323
反应条件
potassium hydroxide; lithium chloride in 1,4-dioxane
T=10 - 15°C; Addition;
参考文献
Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Lain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 900 - 910
反应条件
hydrogenchloride
Heating;
参考文献
Kamata, Kazuyuki; Terashima, Masanao
Journal of the Chemical Society, Chemical Communications, 1994 , # 24 p. 2771 - 2772
反应条件
1: sodium metabisulfite / H2O
2: HCl / H2O / 12 h / 20 °C
View Scheme
参考文献
Guieysse, David; Salagnad, Christophe; Monsan, Pierre; Remaud-Simeon, Magali
Tetrahedron Asymmetry, 2003 , vol. 14, # 3 p. 317 - 323
反应条件
potassium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
T=55°C; 1 h;
参考文献
Meng, Qinghua; Sun, Yanhui; Ratovelomanana-Vidal, Virginie; Genet, Jean Pierre; Zhang, Zhaoguo
Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3842 - 3847
反应条件
1: 68 percent / triethylamine / tetrahydrofuran / 18 h / -20 °C
2: 25 percent / cc. aq. HCl / 4 h / Heating
View Scheme
参考文献
Mizuno, Masanori; Shioiri, Takayuki
Tetrahedron Letters, 1998 , vol. 39, # 50 p. 9209 - 9210
反应条件
1: 70 percent / LDA / tetrahydrofuran / 3.5 h / -75 °C
2: 77 percent / 3 M HCl / Heating
View Scheme
参考文献
Kamata, Kazuyuki; Terashima, Masanao
Journal of the Chemical Society, Chemical Communications, 1994 , # 24 p. 2771 - 2772
反应条件
1: 50percent NaOH, Bu4NBr / tetrahydrofuran
2: 70 percent / LDA / tetrahydrofuran / 3.5 h / -75 °C
3: 77 percent / 3 M HCl / Heating
View Scheme
参考文献
Kamata, Kazuyuki; Terashima, Masanao
Journal of the Chemical Society, Chemical Communications, 1994 , # 24 p. 2771 - 2772
参考文献
Lapkin; Ljubimowa
Zhurnal Obshchei Khimii, 1948 , vol. 18, p. 701,704
Chem.Abstr., 1949 , p. 188
