1.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 1.2: 2 h / 20 °C / Inert atmosphere 2.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere 3.1: hydrogenchloride / ethanol; water / Reflux View Scheme

sodium hydroxide in ethanol Heating;

tetrafluoroboric acid diethyl ether complex; N-bromosuccinmide in acetonitrile 2 h; Ambient temperature; Yield given. Yields of byproduct given;

sulfuric acid Reaktion ueber mehrere Stufen;

N-bromosuccinmide in acetonitrile 1.5 h; Ambient temperature; Further byproducts given;

1: With β-cyclodextrin 12 h; 2: With bromine in methanol; tetrachloromethane T=20°C; 2 h; Further stages.;

1.1: s-BuLi; TMEDA / cyclohexane; hexane; tetrahydrofuran / 2 h / -78 °C 1.2: 64 percent / 1,2-dibromoethane / tetrahydrofuran; hexane; cyclohexane / -78 - 20 °C 2.1: 82 percent / NaOH / ethanol / Heating View Scheme