4-[2-(5-乙基-2-吡啶)乙氧基]苯胺合成路线 （共 9 条）
反应条件
1: With hydrogen bromide in methanol; water; acetone T=10 - 30°C; 0.5 h; 2: With copper(I) oxide; sodium nitrite in methanol; water; acetone T=0 - 42°C; 2.75 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/117654 A1, 2006 ;
Location in patent: Page/Page column 9-14 ;
反应条件
copper(I) oxide; hydrogen bromide; sodium nitrite 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C; Yield given. Multistep reaction;
参考文献
Richter, Jindrich; Jirman; Havlicek; Hrdina
Pharmazie, 2007 , vol. 62, # 8 p. 580 - 584
反应条件
1: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 2: 53 percent / NaOAc / ethanol / Heating View Scheme
参考文献
Sohda; Momose; Meguro; Kawamatsu; Sugiyama; Ikeda
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 1 p. 37 - 42
反应条件
1: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 2: 53 percent / NaOAc / ethanol / Heating 3: 2N HCl / 6 h / Heating 4: 12.2 g / 11percent ethanolic HCl / 1 h / Ambient temperature View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 40, # 1 p. 37 - 42
反应条件
1: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 2: 53 percent / NaOAc / ethanol / Heating 3: 2N HCl / 6 h / Heating View Scheme
参考文献
Sohda; Momose; Meguro; Kawamatsu; Sugiyama; Ikeda
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 1 p. 37 - 42
反应条件
1: 1.)47percent HBr, NaNO2, 2.)Cu2O / 1.)MeOH, H2O, 5 deg C, 20 min., 2.)40 deg C 2: 70percent m-chloroperbenzoic acid / methanol / Heating 3: 80 °C 4: NaOAc / ethanol / Heating 5: 3N HCl / Heating View Scheme
参考文献
Sohda; Momose; Meguro; Kawamatsu; Sugiyama; Ikeda
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 1 p. 37 - 42
反应条件
hydrogen; Raney nickel in methanol
T=-15 - 30°C; P=2206.72 - 2942.29 Torr; Product distribution / selectivity;
参考文献
MOREPEN LABORATORIES LIMITED
Patent: WO2006/35459 A1, 2006 ;
Location in patent: Page/Page column 21; 22 ;
反应条件
1: KOH / CH2Cl2
2: Raney nickel / methanol
View Scheme
参考文献
Kumar; Reddy; Eswaraiah; Mukkanti; Suryanarayana
Pharmazie, 2004 , vol. 59, # 11 p. 836 - 839
反应条件
1: KOH / CH2Cl2
2: Raney nickel / methanol
View Scheme
参考文献
Kumar; Reddy; Eswaraiah; Mukkanti; Suryanarayana
Pharmazie, 2004 , vol. 59, # 11 p. 836 - 839
