2-溴-3,5-二甲氧基苯甲醛合成路线 （共 13 条）
反应条件
1: With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran T=-78°C; 0.75 h; 2: With tert.-butyl lithium in tetrahydrofuran; pentane T=-78 - 20°C;
参考文献
Tan, Jason Samuel; Ciufolini, Marco A.
Organic Letters, 2006 , vol. 8, # 21 p. 4771 - 4774
反应条件
1: acetic acid; bromine 2: concentrated aqueous KOH View Scheme
参考文献
Lock; Nottes
Monatshefte fuer Chemie, 1936 , vol. 68, p. 51,60
反应条件
n-butyllithium; nitrobenzene 1.) THF, hexane, -75 deg C, 50 min.; 2.) -75 deg C, 4h, -> room temp.; Yield given. Multistep reaction;
参考文献
Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 1941 - 1944
反应条件
bromine in water; acetic acid
T=20°C;
参考文献
Tan, Jason Samuel; Ciufolini, Marco A.
Organic Letters, 2006 , vol. 8, # 21 p. 4771 - 4774
反应条件
sodium hydrogencarbonate; pyridinium chlorochromate in dichloromethane
T=0 - 20°C; 4 h; Inert atmosphere;
参考文献
Rink, Christian; Sasse, Florenz; Zubrienae -, Asta; Matulis, Daumantas; Maier, Martin E.
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14469 - 14478
反应条件
bromine in acetic acid
T=5°C;
参考文献
Keay; Rodrigo
Journal of the American Chemical Society, 1982 , vol. 104, # 17 p. 4725 - 4727
反应条件
N-bromosuccinmide; pyridinium chlorochromate
1.) CCl4; 2.) CH2Cl2; Multistep reaction;
参考文献
Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 1941 - 1944
反应条件
1: 92 percent / LiAlH4 / tetrahydrofuran / 10 h / Ambient temperature
2: 96 percent / NBS / CHCl3 / 45 °C
3: 90 percent / PDC / CHCl3
View Scheme
参考文献
Rama Rao; Chakraborty; Joshi
Tetrahedron Letters, 1992 , vol. 33, # 28 p. 4045 - 4048
反应条件
1: sulfuric acid / 20 h / 0 °C / Reflux
2: sodium tetrahydroborate / tetrahydrofuran; methanol / 1.67 h / Reflux
3: manganese(IV) oxide / toluene / 15 h / Reflux
4: 1,3-dibromo-5,5-dimethyl-hydantoin / chloroform / 0 - 20 °C
View Scheme
参考文献
Takada, Akiomi; Hashimoto, Yoshimitsu; Takikawa, Hiroshi; Hikita, Katsuyoshi; Suzuki, Keisuke
Angewandte Chemie - International Edition, 2011 , vol. 50, # 10 p. 2297 - 2301
反应条件
water; copper; sodium hydroxide
24 h; Reflux;
参考文献
Liao, Yu-Ren; Liang, Jun-Weil; Wu, Tian-Shung; Kuo, Ping-Chung; Huang, Shiow-Chyn
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6202 - 6204,3
