4-[3-(三氟甲基)-3H-双吖丙啶-3-基]苯甲酸合成路线 （共 34 条）
反应条件
potassium permanganate in pyridine; water T=50°C; 20 h;
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
potassium hydroxide; potassium permanganate in 1,4-dioxane 2 h; Ambient temperature;
参考文献
Nassal, Michael
Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523
反应条件
iodine; triethylamine in methanol T=20°C; 0.333333 h;
参考文献
European Journal of Organic Chemistry, , # 23 p. 3870 - 3878
反应条件
1: I2; Et3N 2: KMnO4; pyridine View Scheme
参考文献
Chemistry Letters, , vol. 35, # 10 p. 1172 - 1173
反应条件
1: 97 percent / imidazole 2: 1) n-BuLi / 1) hexane, ether, -30 to 0 deg C in 2 h, 2) ether, -50 deg C, 3 h 3: 93 percent / NH3OHCl, NaOH / ethanol / 16 h / Heating 4: 70 percent / pyridine / 3 h / Heating 5: 86 percent / liq. NH3 / diethyl ether / 12 h / Ambient temperature 6: 91 percent / Ag2O / diethyl ether / 1 h 7: 92 percent / conc. HCl / methanol 8: 72 percent / 0.2N KOH, KMnO4 / dioxane / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
反应条件
1: hydroxylamine 2: pyridine 3: NH3 (liquid) 4: I2; Et3N 5: KMnO4; pyridine View Scheme
参考文献
Chemistry Letters, , vol. 35, # 10 p. 1172 - 1173
反应条件
1.1: 99 percent / NEt3; DMAP / CH2Cl2 / 3 h / 20 °C 2.1: 86 percent / ammonia (g) / CH2Cl2 / 18 h / -78 - 20 °C 3.1: 95 percent / NEt3 / CH2Cl2 / 4 h / -78 - 20 °C 4.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 4.2: 89 percent / tetrahydrofuran; hexane / 16 h / -78 °C 5.1: NEt3; iodine / methanol / 0.33 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 3870 - 3878
反应条件
1.1: 86 percent / ammonia (g) / CH2Cl2 / 18 h / -78 - 20 °C 2.1: 95 percent / NEt3 / CH2Cl2 / 4 h / -78 - 20 °C 3.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 3.2: 89 percent / tetrahydrofuran; hexane / 16 h / -78 °C 4.1: NEt3; iodine / methanol / 0.33 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 3870 - 3878
反应条件
1.1: 95 percent / NEt3 / CH2Cl2 / 4 h / -78 - 20 °C 2.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 89 percent / tetrahydrofuran; hexane / 16 h / -78 °C 3.1: NEt3; iodine / methanol / 0.33 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 3870 - 3878
反应条件
1.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 89 percent / tetrahydrofuran; hexane / 16 h / -78 °C 2.1: NEt3; iodine / methanol / 0.33 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 3870 - 3878
