1: [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(2-hydroxypropan-2-yl)phenyl]propyl]thio] methyl]-cyclopropane acetic acid methyl ester With sodium hydroxide; water in water; toluene T=40 - 50°C; 15 h; 2: N,N-dicyclohexylamine in acetone T=25 - 35°C; 10 h; Product distribution / selectivity;

water; sodium hydroxide in tetrahydrofuran; methanol T=10 - 20°C; Product distribution / selectivity;

sodium hydroxide in tetrahydrofuran; methanol; water T=24 - 27°C; 20 h; Alkaline aqueous solution; Product distribution / selectivity;