5-((4-乙氧基-3-甲氧基苯基)甲基)-2,4-嘧啶二胺合成路线 （共 4 条）
反应条件
sodium methylate in ethanol
24 h; Heating;
参考文献
Hachtel; Haller; Seydel
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 12 p. 1778 - 1783
反应条件
1: Na-methylate / dimethylsulfoxide / 0.5 h / 65 - 75 °C
2: HCl cc. / propan-2-ol / 1 h / Heating
3: 67 percent / Na-methylate / ethanol / 24 h / Heating
View Scheme
参考文献
Hachtel; Haller; Seydel
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 12 p. 1778 - 1783
反应条件
1: HCl cc. / propan-2-ol / 1 h / Heating
2: 67 percent / Na-methylate / ethanol / 24 h / Heating
View Scheme
参考文献
Hachtel; Haller; Seydel
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 12 p. 1778 - 1783
反应条件
in ethanol; dimethyl sulfoxide
参考文献
Sirichaiwat, Chawanee; Intaraudom, Chakapong; Kamchonwongpaisan, Sumalee; Vanichtanankul, Jarunee; Thebtaranonth, Yodhathai; Yuthavong, Yongyuth
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 345 - 354
