2-氧代-5,6,7,8-四氢-2H-色烯-3-羧酸甲酯合成路线 （共 5 条）
反应条件
1: 83 percent / 1,3,5-trimethyl-benzene / 40 h / 180 °C 2: 100 percent / 0.67N aqueous NaOH / tetrahydrofuran / 1) 20h, 40 deg C 2) 5h, 60 deg C 3: 88 percent / copper / quinoline / 4 h / 260 °C View Scheme
参考文献
Boger, Dale L.; Mullican, Michael D.
Tetrahedron Letters, 1983 , vol. 24, # 45 p. 4939 - 4942
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-30 - 25°C; 2.75 h;
参考文献
Boger, Dale B.; Mullican, Michael D.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4033 - 4044
反应条件
in tetrahydrofuran
1.) -78 deg C, 14 h, 2.) 0 deg C, 12 h;
参考文献
Demir; Tanyeli; Urkmez-Karaaslan; Sayrac
Synthetic Communications, 1991 , vol. 21, # 14 p. 1433 - 1441
反应条件
in 1,3,5-trimethyl-benzene
T=180°C; 40 h;
参考文献
Boger, Dale L.; Mullican, Michael D.
Tetrahedron Letters, 1983 , vol. 24, # 45 p. 4939 - 4942
Title/Abstract Full Text View citing articles Show Details
Boger, Dale B.; Mullican, Michael D.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4033 - 4044
反应条件
1: 2) methanesulfonic acid / 1) 78h, 150 deg C 2) benzene, 5h, 25 deg C
2: 99 percent / 1.0N aqueous NaOH / tetrahydrofuran / 20 h / 60 °C
3: 1) K2CO3 2) oxalyl chloride / 1) THF-H2O (4:1), 1h, 25 deg C 2) benzene, a) 1.75h, 25 deg C b) 10min, reflux
4: 86 percent / tetrahydrofuran / -78 °C
5: 67 percent / m-CPBA / CH2Cl2 / 84 h / 40 °C
View Scheme
参考文献
Boger, Dale L.; Mullican, Michael D.
Tetrahedron Letters, 1983 , vol. 24, # 45 p. 4939 - 4942
