(S)-1,2-十二烷二醇合成路线 （共 16 条）
反应条件
water; isopropyl alcohol; Jacobsen catalyst (R,R)-salen-Co(OAc) in dichloromethane T=20°C; CoolingInert atmosphere;
参考文献
MASSACHUSETTS INSTITUTE OF TECHNOLOGY; MAHON, Kerry, Peter; LOVE, Kevin, Thomas; LEVINS, Christopher, G.; WHITEHEAD, Kathryn, Ann; LANGER, Robert, S.; ANDERSON, Daniel, Griffith
Patent: WO2010/53572 A2, 2010 ;
Location in patent: Page/Page column 160 ;
反应条件
hydrogenchloride in methanol T=20°C;
参考文献
Zeng, Bu-Bing; Wu, Yikang; Jiang, Sheng; Yu, Qian; Yao, Zhu-Jun; Liu, Zhong-Hai; Li, Hong-Yan; Li, Yan; Chen, Xiao-Guang; Wu, Yu-Lin
Chemistry - A European Journal, 2003 , vol. 9, # 1 p. 282 - 290
反应条件
1: With hydrogen; palladium on activated charcoal in methanol 2: With hydrogenchloride in methanol
参考文献
Liu, Hai-Xia; Yao, Zhu-Jun
Tetrahedron Letters, 2005 , vol. 46, # 20 p. 3525 - 3528
反应条件
1.1: H2 / Pd/C / methanol 1.2: 88 percent / HCl / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 20 p. 3525 - 3528
反应条件
1.1: 2.5 h / 140 °C 2.1: BuLi / tetrahydrofuran / 0.5 h / -20 °C 2.2: 91 percent / tetrahydrofuran / 4 h / 20 °C 3.1: 96 percent / H2; NEt3 / 10percent Pd/C / methanol / 24 h / 20 °C 4.1: 94 percent / aq. HCl / methanol / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 9, # 1 p. 282 - 290
反应条件
1.1: BuLi / tetrahydrofuran / 0.5 h / -20 °C 1.2: 91 percent / tetrahydrofuran / 4 h / 20 °C 2.1: 96 percent / H2; NEt3 / 10percent Pd/C / methanol / 24 h / 20 °C 3.1: 94 percent / aq. HCl / methanol / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 9, # 1 p. 282 - 290
反应条件
1: di(n-butyl)tin oxide; triethylamine / dichloromethane 2: potassium carbonate / methanol / 0 - 20 °C 3: acetic acid; Co{(OC6H4CHN)2(C6H10)} / water; dichloromethane; tetrahydrofuran View Scheme
参考文献
European Journal of Organic Chemistry, , # 30 p. 6886 - 6899
反应条件
methanol; Candida antartica lipase B in acetonitrile T=20°C; 48 h; Enzymatic reaction;
参考文献
Parve, Omar; Reile, Indrek; Parve, Jaan; Kasvandik, Sergo; Kudrjasova, Marina; Tamp, Sven; Metsala, Andrus; Villo, Ly; Pehk, Tonis; Jarvet, Jueri; Vares, Lauri
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12795 - 12801
反应条件
1: (S,S)-(salen)Co(II)complex; acetic acid / water; tetrahydrofuran / 16.08 h / 0 - 20 °C / |Resolution of racemate 2: acetic acid; Co{(OC6H4CHN)2(C6H10)} / water; dichloromethane; tetrahydrofuran View Scheme
参考文献
European Journal of Organic Chemistry, , # 30 p. 6886 - 6899
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C 2: (S,S)-(salen)Co(II)complex; acetic acid / water; tetrahydrofuran / 16.08 h / 0 - 20 °C / |Resolution of racemate 3: acetic acid; Co{(OC6H4CHN)2(C6H10)} / water; dichloromethane; tetrahydrofuran View Scheme
参考文献
European Journal of Organic Chemistry, , # 30 p. 6886 - 6899
