4-溴-3-甲基异噻唑-5-胺合成路线 （共 3 条）
反应条件
N-bromosuccinmide in tetrachloromethane T=20 - 65°C; 1.66667 h;
参考文献
Schering Corporation
Patent: US2007/117804 A1, 2007 ;
Location in patent: Page/Page column 76-77 ;
US 20070117804 A1
反应条件
1: With bromine; acetic acid in benzene T=10°C; 2: With sodium carbonate in water
参考文献
WO2004/33423 A2, ;
Page 39-40; 42 ;
反应条件
(i) aq. NaNO2, H2SO4, H3PO4, (ii) aq. H3PO2, Cu2O; Multistep reaction;
参考文献
Buttimore,D. et al.
Journal of the Chemical Society, 1963 , p. 2032 - 2039
