N1,N4-双-Boc-亚精胺合成路线 （共 12 条）
反应条件
sodium hydroxide; hydrogen; nickel in ethanol
参考文献
Hu, Wenqiag; Hesse, Manfred
Helvetica Chimica Acta, 1996 , vol. 79, # 2 p. 548 - 559
反应条件
1: 20 percent / Et3N / methanol / 20 °C
2: 57 percent / K2CO3 / acetonitrile / 24 h / 60 °C
3: 100 percent / Et3N / methanol / 20 °C
4: 64 percent / NH4OH; NH3; H2 / Raney nickel / ethanol / 24 h / 1810.07 Torr
View Scheme
参考文献
Oves-Costales, Daniel; Kadi, Nadia; Fogg, Mark J.; Song, Lijiang; Wilson, Keith S.; Challis, Gregory L.
Journal of the American Chemical Society, 2007 , vol. 129, # 27 p. 8416 - 8417
反应条件
1: 57 percent / K2CO3 / acetonitrile / 24 h / 60 °C
2: 100 percent / Et3N / methanol / 20 °C
3: 64 percent / NH4OH; NH3; H2 / Raney nickel / ethanol / 24 h / 1810.07 Torr
View Scheme
参考文献
Oves-Costales, Daniel; Kadi, Nadia; Fogg, Mark J.; Song, Lijiang; Wilson, Keith S.; Challis, Gregory L.
Journal of the American Chemical Society, 2007 , vol. 129, # 27 p. 8416 - 8417
反应条件
1: 100 percent / Et3N / methanol / 20 °C
2: 64 percent / NH4OH; NH3; H2 / Raney nickel / ethanol / 24 h / 1810.07 Torr
View Scheme
参考文献
Oves-Costales, Daniel; Kadi, Nadia; Fogg, Mark J.; Song, Lijiang; Wilson, Keith S.; Challis, Gregory L.
Journal of the American Chemical Society, 2007 , vol. 129, # 27 p. 8416 - 8417
反应条件
hydrogen; palladium on activated charcoal in methanol
4 h; Ambient temperature;
参考文献
Levchine; Rajan; Borloo; Bollaert; Hamers
Synthesis, 1994 , # 1 p. 37 - 39
反应条件
water; potassium carbonate in methanol; water
2.16667 h; Heating;
参考文献
Bergeron, Raymond J.; McManis, James S.
Journal of Organic Chemistry, 1987 , vol. 52, # 9 p. 1700 - 1703
反应条件
1: 4 Angstroem molecular sieves / tetrahydrofuran / 1 h
2: sodium cyanoborohydride, p-TsOH / tetrahydrofuran
3: 89 percent / Et3N / CH2Cl2 / Ambient temperature
4: 92 percent / H2 / 10percent Pd-C / methanol / 4 h / Ambient temperature
View Scheme
参考文献
Levchine; Rajan; Borloo; Bollaert; Hamers
Synthesis, 1994 , # 1 p. 37 - 39
反应条件
1: 82 percent / AcOH, H2O / 10 h / Ambient temperature
2: 4 Angstroem molecular sieves / tetrahydrofuran / 1 h
3: sodium cyanoborohydride, p-TsOH / tetrahydrofuran
4: 89 percent / Et3N / CH2Cl2 / Ambient temperature
5: 92 percent / H2 / 10percent Pd-C / methanol / 4 h / Ambient temperature
View Scheme
参考文献
Levchine; Rajan; Borloo; Bollaert; Hamers
Synthesis, 1994 , # 1 p. 37 - 39
反应条件
1: 89 percent / Et3N / CH2Cl2 / Ambient temperature
2: 92 percent / H2 / 10percent Pd-C / methanol / 4 h / Ambient temperature
View Scheme
参考文献
Levchine; Rajan; Borloo; Bollaert; Hamers
Synthesis, 1994 , # 1 p. 37 - 39
反应条件
ammonium hydroxide in ethanol
48 h; Ambient temperature; Yield given;
参考文献
Lebreton, Luc; Annat, Jocelyne; Derrepas, Philippe; Dutartre, Patrick; Renaut, Patrice
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 277 - 290
