(1-甲基-1H-吲哚-7-基)甲醇合成路线 （共 5 条）
反应条件
sodium tetrahydroborate; ethanol
T=0 - 20°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/269737 A1, 2011 ;
Location in patent: Page/Page column 40 ;
US 20110269737 A1
反应条件
sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; Cooling with ice;
参考文献
Gaisina, Irina N.; Gallier, Franck; Ougolkov, Andrei V.; Kim, Ki H.; Kurome, Toru; Guo, Songpo; Holzle, Denise; Luchini, Doris N.; Blond, Sylvie Y.; Billadeau, Daniel D.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 7 p. 1853 - 1863
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
2: sodium tetrahydroborate / methanol / 0 °C
View Scheme
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
反应条件
1: tetrahydrofuran / -40 - 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
3: sodium tetrahydroborate / methanol / 0 °C
View Scheme
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
反应条件
1: toluene-4-sulfonic acid / toluene / Reflux
2: tetrahydrofuran / -40 - 20 °C
3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
4: sodium tetrahydroborate / methanol / 0 °C
View Scheme
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
