1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide (EDC) / dimethylformamide / 40 °C 2: H2 / 15percent Pd/C / dimethylformamide / 2 h / 3102.9 Torr / Ambient temperature 3: DCC / dimethylformamide / 1.) 0 deg C, 1h, 2.) 40 deg C, overnight 4: NaHCO3 / dioxane; H2O / 1.) RT, 1 h, 2.) 40 deg C, 2 h View Scheme

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide (EDC) / dimethylformamide / 40 °C 2: H2 / 15percent Pd/C / dimethylformamide / 2 h / 3102.9 Torr / Ambient temperature 3: DCC / dimethylformamide / 1.) 0 deg C, 1h, 2.) 40 deg C, overnight 4: NaHCO3 / dioxane; H2O / 1.) RT, 1 h, 2.) 40 deg C, 2 h View Scheme

1: H2 / 15percent Pd/C / dimethylformamide / 2 h / 3102.9 Torr / Ambient temperature 2: DCC / dimethylformamide / 1.) 0 deg C, 1h, 2.) 40 deg C, overnight 3: NaHCO3 / dioxane; H2O / 1.) RT, 1 h, 2.) 40 deg C, 2 h View Scheme

1: DCC / dimethylformamide / 1.) 0 deg C, 1h, 2.) 40 deg C, overnight 2: NaHCO3 / dioxane; H2O / 1.) RT, 1 h, 2.) 40 deg C, 2 h View Scheme

sodium hydrogencarbonate in 1,4-dioxane; water 1.) RT, 1 h, 2.) 40 deg C, 2 h;